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pentobarbital will reduce the level or effect of cortisone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will decrease the extent or outcome of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lessen the extent or influence of irinotecan liposom